!!GENETIC_CODE 1.0 transl_table = 5 This file contains the Invertebrate Mitochondrial Code specified in the feature table definition, Version 1.08, formatted for use with the GCG programs (Data Files volume of the Data Reference Set). It names amino acids in both one and three-letter form and lists the codons which should translate into them. All GCG translation programs may generate their translations from the unambiguous codons in this table. Codons which are all lower case are start codons. Alternative Initiation Codons: AUA, AUU AUC: Apis (Crozier and Crozier, 1993) GUG: Polyplacophora (Boore and Brown, 1994) UUG: Ascaris, Caenorhabditis Systematic Range: Nematoda: Ascaris, Caenorhabditis; Mollusca: Bivalvia (Hoffmann et al., 1992); Polyplacophora (Boore and Brown, 1994) Arthropoda/Crustacea: Artemia (Batuecas et al., 1988); Arthropoda/Insecta: Drosophila [Locusta migratoria (migratory locust), Apis mellifera (honeybee)] Comments: * The codon AGG is absent in Drosophila. * GUG may possibly function as an initiator in Drosophila (Clary and Wolstenholme, 1985; Gadaleta et al., 1988). AUU is not used as an initiator in Mytilus (Hoffmann et al., 1992). * "An exceptional mechanism must operate for initiation of translation of the cytochrome oxidase subunit I mRNA in both D. melanogaster (de Bruijn, 1983) and D. yakuba (Clary and Wolstenholme 1983), since its only plausible initiation codon, AUA, is out of frame with the rest of the gene. Initiation appears to require the "reading" of of an AUAA quadruplet, which would be equivalent to initiation at AUA followed immediately by a specific ribosomal frameshift. Another possible mechanism . . . is that the mRNA is "edited" to bring the AUA initiation into frame." (Fox, 1987) Differences from the Standard Code: Code 5 Standard AGA Ser S Arg R AGG Ser S Arg R AUA Met M Ile I UGA Trp W Ter * The Invertebrate Mitochondrial Code Symbol 3-letter Codons ! IUPAC .. A Ala GCT GCC GCA GCG ! GCX B Asx ! RAY C Cys TGT TGC ! TGY D Asp GAT GAC ! GAY E Glu GAA GAG ! GAR F Phe TTT TTC ! TTY G Gly GGT GGC GGA GGG ! GGX H His CAT CAC ! CAY I Ile att atc ! ATH J ??? ... ! ... K Lys AAA AAG ! AAR L Leu TTA ttg CTT CTC CTA CTG ! TTR CTX YTR M Met atg ata ! ATR N Asn AAT AAC ! AAY O ??? ... ! ... P Pro CCT CCC CCA CCG ! CCX Q Gln CAA CAG ! CAR R Arg CGT CGC CGA CGG ! CGX S Ser TCT TCC TCA TCG AGT AGC AGA AGG ! TCX AGX T Thr ACT ACC ACA ACG ! ACX U ??? ... ! ... V Val GTT GTC GTA gtg ! GTX W Trp TGG TGA ! TGR X Xxx ! XXX Y Tyr TAT TAC ! TAY Z Glx ! SAR . ... ... ! ... * End TAA TAG ! TAR